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CD13-mediated FAK/Src/IQGAP1/ARF6 signaling promotes protrusion formation. ( a ) Treatment with inhibitors of major actin-organizing proteins such as FAK (FAK14; 20 μM), Src (PP2; 10 μM) or Cdc42 <t>(ML141;</t> 20 μM) significantly inhibits protrusion formation in WT KSCs, indicating that these proteins are critical for regulating actin cytoskeletal proteins in the formation of protrusions. ( b ). Representative images showing IQGAP1 or ARF6 (green) and phalloidin (actin; red) staining under CM or crosslinking (mAb 452; 1.8 µg/mL) conditions. ( c - d ) Quantification of Pearson Correlation Coefficient (PCC) between IQGAP1 and phalloidin ( c ) and ARF6 and phalloidin ( d ) staining following treatment with either CM or mAb 452. Treatment with mAb 452 significantly increased the correlation between IQGAP1 and phalloidin as well as ARF6 and phalloidin at the membrane. Data are represented as mean ± standard error and consists of at least three independent experiments with at least 5–10 images taken per treatment condition. *p < 0.05.
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CD13-mediated FAK/Src/IQGAP1/ARF6 signaling promotes protrusion formation. ( a ) Treatment with inhibitors of major actin-organizing proteins such as FAK (FAK14; 20 μM), Src (PP2; 10 μM) or Cdc42 <t>(ML141;</t> 20 μM) significantly inhibits protrusion formation in WT KSCs, indicating that these proteins are critical for regulating actin cytoskeletal proteins in the formation of protrusions. ( b ). Representative images showing IQGAP1 or ARF6 (green) and phalloidin (actin; red) staining under CM or crosslinking (mAb 452; 1.8 µg/mL) conditions. ( c - d ) Quantification of Pearson Correlation Coefficient (PCC) between IQGAP1 and phalloidin ( c ) and ARF6 and phalloidin ( d ) staining following treatment with either CM or mAb 452. Treatment with mAb 452 significantly increased the correlation between IQGAP1 and phalloidin as well as ARF6 and phalloidin at the membrane. Data are represented as mean ± standard error and consists of at least three independent experiments with at least 5–10 images taken per treatment condition. *p < 0.05.
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CD13-mediated FAK/Src/IQGAP1/ARF6 signaling promotes protrusion formation. ( a ) Treatment with inhibitors of major actin-organizing proteins such as FAK (FAK14; 20 μM), Src (PP2; 10 μM) or Cdc42 (ML141; 20 μM) significantly inhibits protrusion formation in WT KSCs, indicating that these proteins are critical for regulating actin cytoskeletal proteins in the formation of protrusions. ( b ). Representative images showing IQGAP1 or ARF6 (green) and phalloidin (actin; red) staining under CM or crosslinking (mAb 452; 1.8 µg/mL) conditions. ( c - d ) Quantification of Pearson Correlation Coefficient (PCC) between IQGAP1 and phalloidin ( c ) and ARF6 and phalloidin ( d ) staining following treatment with either CM or mAb 452. Treatment with mAb 452 significantly increased the correlation between IQGAP1 and phalloidin as well as ARF6 and phalloidin at the membrane. Data are represented as mean ± standard error and consists of at least three independent experiments with at least 5–10 images taken per treatment condition. *p < 0.05.

Journal: Scientific Reports

Article Title: CD13 activation assembles phosphoinositide (PI) signaling complexes to regulate the actin cytoskeleton

doi: 10.1038/s41598-026-35022-6

Figure Lengend Snippet: CD13-mediated FAK/Src/IQGAP1/ARF6 signaling promotes protrusion formation. ( a ) Treatment with inhibitors of major actin-organizing proteins such as FAK (FAK14; 20 μM), Src (PP2; 10 μM) or Cdc42 (ML141; 20 μM) significantly inhibits protrusion formation in WT KSCs, indicating that these proteins are critical for regulating actin cytoskeletal proteins in the formation of protrusions. ( b ). Representative images showing IQGAP1 or ARF6 (green) and phalloidin (actin; red) staining under CM or crosslinking (mAb 452; 1.8 µg/mL) conditions. ( c - d ) Quantification of Pearson Correlation Coefficient (PCC) between IQGAP1 and phalloidin ( c ) and ARF6 and phalloidin ( d ) staining following treatment with either CM or mAb 452. Treatment with mAb 452 significantly increased the correlation between IQGAP1 and phalloidin as well as ARF6 and phalloidin at the membrane. Data are represented as mean ± standard error and consists of at least three independent experiments with at least 5–10 images taken per treatment condition. *p < 0.05.

Article Snippet: ML141 , 20 μM , Tocris; 4266.

Techniques: Staining, Membrane